Dissertation
Dissertation > Medicine, health > Basic Medical > Pathology > Pathological anatomy and histology

Expression of Fos in Central Nevrous System and NOS in Gastric Mucosa after Ethanol-induced Acute Gastritis in Rat

Author LiuJun
Tutor GanZiMing
School Xinjiang Medical University
Course Human Anatomy and Embryology
Keywords Acute gastritis Fos NOS central nervous system Gastric mucosa
CLC R361
Type Master's thesis
Year 2005
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Objective: To study the expression and significance of Fos in central nervous system and NOS in gastric mucosa after ethanol-induced acute gastritis in rat. Methods: Animals were randomly classified into 5 groups:gaster-poured by physiological solution(A); gaster-poured by ethanol(B); gaster-poured by ethanol after hypophrenic vagotomy(C); gaster-poured by ethanol after big-small splanchnicotomy(D); gaster-poured by ethanol after hypophrenic vagotomy and big-small splanchni-cotomy(E). LI was studied.The distribution of Fos-positive neuron in central nervous system and NOS-positive cell in gastric mucosa was displayed and immunohistochemical staining method was used. Results: There were a lot of Fos-positive neuron in thalamus ventral-lateral nucleus and No 9 thoracic medullaris posterior horn cinerea in groups B and C; Fos-positive neuron in ambiguous nucleus and nucleus of solitary tract were better in groups B and D, but they were obiviously less than them of halamus ventral-lateral nucleus and No 9 thoracic medullaris posterior horncinerea in groups B and C(P<0.05). LI of groups B and D were higher than them of group A(P<0.05). but them were obiviously much higher than them of groups C and E(P<0.05). There were a lot of NOS I -positive cell in mucosa of gastric body in groups A、 B and D. And them were obiviously much more than them of groups C and E(P<0.05)There were a lot of NOS II -positive cell in mucosa of gastric body in groups C and E. And them were obiviously much more than them of groups A、 B and D(P<0.05). Conclusion: The gastric algesia impulsion are mainly conducted by sympathetic afferent nerve. And NO protecting mucosa of gastric body are mainly introduced by vagus nerve.

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