Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug > Heterocyclic compounds drugs > Five section heterocyclic

Study on the Synthesis of Intermediate of Atorvastatin

Author LiuWei
Tutor ZhengGuoJun
School Beijing University of Chemical Technology
Course Biochemical Engineering
Keywords HMG-CoA reductase inhibitor atorvastatin synthesis
CLC TQ463.53
Type Master's thesis
Year 2006
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Atorvastatin is a inhibitor of HMG-CoA reductase, which is able to reduce high lipid density by inhibiting the HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis. cholesterol. Many clinical studies indicated that statins are usually better than most other lipid adjusting medicine. Moreover, it can be used to prevent fracture, cure osteoporosis, regulate immunity, etc.This paper concentrates on the synthesis of 4-fluoro- α -(2-methyl -1-oxopropy)- γ -oxo-N, β -diphenylbenzenebutaneamide, one of the key intermediate of atorvastatin. Several steps involved were studied.Isobutyryl chloride was simply acquired by the chlorination of isobutyryl acid with SOCl2, followed by condensation with potassium methyl malonate, giving ethyl isobutyrylacetate as the product. Then isobutyrylethyl acetate was transformed into 4-methyl-3-oxo-N-pentanamide by reaction with aniline; the resulting product could undergo Knoevenagel condensation with benzaldehyde giving 4-methyl-3-oxo-N-phenyl-2-(phenylmethylene) pentanamide, which could further undergo Stetter reaction with

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