Dissertation
Dissertation > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors

The Relationship Among HPV16/18、HSP70、bcl-2 and Cervical Cancer

Author ZhangLiYan
Tutor ZhangAiRong
School Shandong University
Course Obstetrics and Gynaecology
Keywords Cervical cancer (CC) Human papillomavirus (HPV) Heat shock protein 70 (HSP70) bcl-2
CLC R737.33
Type Master's thesis
Year 2005
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The purpose of detection of cervical cancer , cervical carcinoma in situ and normal cervical tissue HPV16/18 infection , as well as heat shock protein of HSP70 , bcl -2 expression levels of expression of HPV16/18 of HSP70, bcl- 2 in cervical cancer development role and relationship . Methods ① 20 cases of normal cervical tissue of the polymerase chain reaction (PCR) technology , the infection of HPV16/18 12 cases of cervical carcinoma in situ and 50 cases of cervical cancer detection , ② using immunohistochemistry to detect the specimens of HSP70 and bcl- 2 protein expression ; ③ data obtained with the Chinese statistical software analysis , comparison and correlation of the rate between the two groups using the chi -square test . Results ① HPV infection in cervical carcinoma in situ and cervical cancer tissues was significantly higher than normal cervical tissue ; ② The expression of HSP70 protein in HPV-DNA - positive group was significantly higher than HPV-DNA - negative group , the expression of HSP70 protein in cervical carcinoma in situ and cervical cancer The tissue was significantly higher than in normal cervical tissue . ③ bcl-2 protein expression in cervical tissue lesions was significantly higher than the normal cervical tissue ; bcl-2 in HPV-DNA positive group was significantly higher than that of HPV-DNA - negative group . Conclusion ① The incidence of cervical cancer are multiple factors involved in the multi- step process , and is closely related to the incidence of HPV infection and cervical cancer , the ② infection stress state of HSP70 , bcl- 2 expression in cervical increase ;

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