Dissertation
Dissertation > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases

Effect of Yiqi-huoxue Formula to Recur of Peptic Ulcer

Author GuoJinWei
Tutor GeHuiNan
School Nanjing University of Traditional Chinese Medicine
Course Chinese medical science
Keywords Yiqihuoxue party Peptic ulcer recurrence Vascular endothelial growth factor Basic fibroblast growth factor Heat shock protein 70 Prostaglandin E2
CLC R259
Type Master's thesis
Year 2009
Downloads 91
Quotes 1
Download Dissertation

Objective: To follow-up in patients with pre-treatment of peptic ulcer healing observed two sets of peptic ulcer recurrence. Clinical symptoms in patients with peptic ulcer score, serum vascular endothelial growth factor (the Vascular EndothelialGrowth Factor VEGF), basic fibroblast growth factor (basic Fibroblast Growth Factor, bFGF), the prostaglandin E 2 (Prostaglandins E 2 , the PGE 2 ), heat shock protein 70 (Heat Shock Proteins-70, HSP-70) target detection, endoscopy observation and ulcer recurrence Factors score of quality of ulcer healing (Quality ofulcer healing, QOUH) with the recurrence of ulcers, hematological parameters and ulcer recurrence, and to explore the mechanism of Yiqihuoxue parties to reduce ulcer recurrence rate, helping to better guide how clinically effective in preventing the recurrence of peptic ulcer. Methods: 30 cases of patients with pre-treatment of peptic ulcer healing included in the follow-up to observe the recurrence of peptic ulcer healing. Rating of clinical symptoms, endoscopy observations, hematology indicators VEGF, bFGF, PGE 2 , HSP-70 testing and factors associated with recurrence score, observed recurrence of the different treatment methods. The preceding study, the treatment group the oral Yiqihuoxue square omeprazole, the control group omeprazole. Hp positive week to triple eradication therapy: omeprazole clarithromycin Amoxicillin. Results: (1) recurrence: In group A, the overall recurrence rate is low compared with western medicine group, but no statistically significant; Chinese and Western medicine group than in the western medicine group endoscopic recurrence severity of clinical symptoms; Chinese and Western medicine group than western medicine group anti-clinical recurrence time long; the regenerative mucosa learn maturity and ulcer recurrence rate relationship: the excellent 2 and HSP70 expression level is higher than the western medicine group, recurrence of VEGF, bFGF and HSP70 expression levels than patients without recurrence, the time of relapse the PGE 2 the expression level is lower than in patients without recurrence, but not statistically significant. (3) the relevant factors and ulcer recurrence: integral statistically significant factors in western medicine group and western medicine group, patients with recurrent factor score was significantly higher than patients without recurrence. Conclusion: Yiqihuoxue in order to reduce the rate of recurrence of peptic ulcer, improve the severity of clinical relapses in patients with symptoms, which may be related through the promotion of VEGF, bFGF, HSP70, PGE 2 of expression, promote angiogenesis improve the quality of ulcer healing related. Significance: This issue through detection of the follow-up of patients with peptic ulcer ulcer recurrence rate and related indicators, analyzing contextual factors affect the recurrence of ulcers and ulcer healing the relationship between the quality and the recurrence of peptic ulcer recurrence explore Yiqihuoxue parties may the mechanism for the clinical treatment to provide a reference.

Related Dissertations
More Dissertations